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Epigenetic Damage
Transposons
Biological Clocks
Antagonistic Pleitropy
Definition:
The Antagonistic Pleiotropy theory of aging is the hypothesis that the genes that cause aging are evolutionarily conserved because these same genes are beneficial to the organism's fitness early on in life.
Origin:
This hypothesis was first proposed by George C. Williams in 1957.
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Argument Against:
Aging is one of the most important characteristics of life on Earth. If aging was not nearly universal in animals, life on Earth would be completely different than it is now. The Theory of Antagonistic Pleiotropy suggest that this very important fact of life on Earth just happens to result from the fact that the pathways of somatic maintence and fitness become crosses, and evolution has never found a way to seperate them.
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Recommendations:
Therapeutics should focus on silencing pleiotropic genes later in an organism's life.
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References:
Williams G.C. 1957. Evolution.
Pleiotropy, natural selection, and the evolution of senescence.
Aging Encyclopedia
and book and article reviews
Bacterial Cross-Feeding
Partial Reprogramming
Caloric Restriction
Extracellular Damage
Mitochondrial Damage
Germ-line Signaling
Diapause
cPG methylation clocks
thymus clock
telemere clock
list of age-associated diseases
long-lived organisms
aging in eusocial organisms
aging in plants
semelparous organisms
seasonality of viruses
cancer caused by programmed immune loss of function
Aging is the increased probability of death from internal causes with the passage of time. There is no reason that aging must occur. That is, it is possible for an organism to grow healthier and healthier with each passing year. Why this is not the human condition is a very interesting question, and is the subject of this site.
You live as if aging cannot be cured because you fear it will not be cured in your lifetime. However, even if aging is not cured in your lifetime, the implications of the fact that aging can be cured are still applicable to you. This site is devoted to articles that discuss these implications.
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Important Observations:
(1) All living things are made up of cells.
A cell is a 1-100 micrometer structure, which consists primarily of a gel-like substance and is enclosed in a phospholipid bi-membrane. All living things are made up of cells. Plants and animals are made up of the same cells that comprise the bodies of microscopic life. In the case of macroscopic life, however, millions to trillions of cells all communicate and coordinate with each other in addition to being physically connected to each other. Although there is a large variety among cells, all known cells are similar enough that they are thought to have had a common ancestor some 3 billion years ago. Cells are broadly classified as either prokaryotic or eukaryotic, depending on whether the cell contains membrane-bound organelles within it. I am not sure whether this binary classification has deep significance or is a matter of convention. It is universally agreed that the observation that all living things are made up of cells implies that multicellular life has unicellular origins, although there is evidence that some unicellular organisms, like yeast, came from multicellular ancestors.
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(2) Cells are reprogrammable, and DNA is the code.
(3) All cells in multicellular organisms contain the same DNA, even though they only express a very small amount of that DNA.
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(4) Cells are not doing their best to survive.
The cells of multicellular organisms routinely undergo an active process of programmed self-destruction for the benefit of the organism or its kin. I suspect cells also actively decrease their own fitness for the benefit of genetically distinct cells, on both the microscopic and macroscopic levels.
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(5) Exponential growth is unsustainable and inevitably follows from replicating life under natural selection at the gene level.
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(6) Population extinction plays a role in evolution. Does beauty?
(7) The universe is as simple as possible, but no simpler.
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